The district is divided into three sub-districts (khwaeng). From west to east, these are:
1. Khlong Toei คลองเตย from the railway to Soi Sukhumvit 22
2. Khlong Tan คลองตัน from Soi Sukhumvit 22 to Soi Sukhumvit 36
3. Phra Khanong พระโขนง from Soi Sukhumvit 36 to Soi Sukhumvit 52

Khlong Toei is both the name of a sub-district and the district in which it lies. Phra Khanong is both a sub-district of Khlong Toei and a district on its own, with only sub-district Bang Chak. Furthermore, all three sub-districts listed above have counterparts with the addition of "nuea" (north) in Watthana District.

Khlong Toei Port, also known as Bangkok Port, was Thailand's only major port for sea transportation of cargo

Bangkok Planetarium
Science Centre for Education
Tamnak Plai Noen, the historic residence of Prince Naris, now converted into a small museum.
The Emporium, a luxury shopping center.
Nana Plaza, a major adult entertainment center, known for prostitution and go-go and hostess bars.
Queen Sirikit National Convention Center, served by the MRT station of the same name, hosts various exhibitions around the year. The venue will be closed for renovation following contract extension.[2]
Benjakitti Park, a public park next to the convention center. It includes a lake and is on land that was formerly occupied by the Tobacco Monopoly, the government's tobacco factory.
Benjasiri Park, a public park created to commemorate Her Majesty Queen Sirikit's 60th birthday. It is next to the Emporium.
Chuvit Garden, a public park in the district created by massage parlor tycoon-turned-politician Chuwit Kamolvisit from his own plot of land, about 2,400 m² in size and worth about 1,250 million baht at the time of opening. Opened in December 2005, it is on Sukhumvit Soi 10.
Khlong Toei Market, Bangkok's largest wet market.
The Khlong Toei slum, south of the expressway and north of the port, is the largest and oldest slum of Bangkok. It houses some 100,000 people on about one square mile (260 ha) of land owned by the Port Authority.
PAT Stadium off Sunthon Kosa Road.
Port Authority of Thailand
Eastern Bus Terminal (Ekkamai)
Thailand Tobacco Monopoly

The following places of interest were formerly in Khlong Toei District:

Lumpinee Boxing Stadium, an indoor Muay Thai arena, now moved to Ram Intra Road, Bang Khen District.
Suan Lum Night Bazaar, closed due to contract expiry, now moved to Suan Lum Night Bazaar Ratchadaphisek.
Stock Exchange of Thailand Building. Now the office is moved to Huai Khwang District.

Diplomatic missions

Embassy of Chile
Embassy of Cuba
Embassy of the Philippines
Embassy of Romania
Embassy of Spain
Embassy of Sudan

• BL23 Queen Sirikit National Convention Centre
  
• BL24 Khlong Toei

BTS skytrain (BTS) stations in the district are Nana, Asok (with interchange to MRT Sukhumvit station), Phrom Phong, Thong Lo, Ekkamai, Phra Khanong, and On Nut, all along Sukhumvit Road on the BTS Sukhumvit Line.

• Nana
  
• Asok + BL22 Sukhumvit
  
• Phrom Phong
  
• Thong Lo
  
• Ekkamai
  
• Phra Khanong
  
• On Nut

Eastern Bus Terminal (also called Ekkamai Bus Terminal) has inter-city buses to destinations such as Pattaya, Rayong and Trat. It is on Sukhumvit Road, near the Ekkamai BTS station.